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Additionally, NAC was anti-inflammatory and did not induce IL-6, IL-8 and IL-1b production ( Figure 9 ), thus providing evidence of its safety as a UTI treatment

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Preclinical studies have also pointed out that AMPK activates SIRT1 by up-regulating the NAD+ levels, which in turn promotes the deacetylation of SIRT1 and activates PGC-1, thereby forming the AMPK-SIRT1-PGC-1 signaling axis